Aminobenzoic acids and derivatives
Medchemexpress LLC NSC243928 mesylate | 59988-01-1 | 99.3% | 503.59 g/mol | C23H25N3O6S2 | 10MM 1ML
NSC243928 mesylate is a small-molecule LY6 (lymphocyte antigen 6) binder with reported antiproliferative and anticancer activity. It is available as a solid and as a ready-to-use 10 mM solution in DMSO for cell-based assays; published data report activity against several breast and ovarian cancer cell lines.
- Binds LY6 family proteins and inhibits cell growth.
- Reported IC50s: MDA-MB-231 5.683 μM; Hs-578-T 7.309 μM; BT-549 7.954 μM; OVCAR-8 4.167 μM.
- Available as solid and 10 mM solution in DMSO (1 mL).
- High purity: 99.33%.
- Molecular formula: C23H25N3O6S2; molecular weight: 503.59 g/mol.
- Soluble in DMSO to 10 mg/mL (≈19.86 mM) with warming.
- Store sealed, away from moisture; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Medchemexpress LLC Exatecan mesylate | 169869-90-3 | 101.1% | 531.55 | 25 MG
Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor primarily used in cancer research. It demonstrates significant inhibition of various cancer cell lines and exhibits antitumor activity in vivo, making it suitable for laboratory centrifugation and storage.
- DNA topoisomerase I inhibitor
- Inhibits proliferation of breast, colon, stomach, and lung cancer cells
- Displays cytotoxic activities against PC-6 and PC-6/SN2-5 cells
- Exhibits antitumor activity in tumor-bearing mice models
- Suppresses lymphatic metastasis and eliminates lung metastasis
- Soluble in H2O at 10 mg/mL and DMSO at 7.41 mg/mL
- For research use only
Medchemexpress LLC Obatoclax mesylate | 803712-79-0 | 99.9% | 413.49 | 1 ML
Obatoclax Mesylate is a BH3 mimetic and a pan-BCL-2 family proteins inhibitor that induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. It exhibits anti-cancer and broad-spectrum antiparasitic activity.
- Inhibits BCL-2 family proteins including BCL-2, BCL-XL, MCL-1, BCL-w, A1, and BCL-b
- Induces autophagy-dependent cell death
- Targets cyclin D1 for proteasomal degradation
- Demonstrates anti-cancer and broad-spectrum antiparasitic activity
- Reduces cell numbers in human colorectal cancer cell lines (HCT116, HT-29, LoVo)
- Increases G1-phase cell populations
- Causes a marked drop in cyclin D1 levels, inhibits GSK3β, and activates p38MAPK
- Shows potent antitumor activity in xenograft mouse models
Apexbio Technology LLC KB-R7943 mesylate 182004-65-5 50mg
KB-R7943 mesylate (CAS 182004-65-5) is a selective inhibitor of the Na /Ca2 exchanger (NCX) particularly effective against its reverse mode It inhibits NCX-mediated Ca2 influx with an IC50 of 0 7 M In transfected Chinese hamster ovary (CHO) cells expressing NCX KB-R7943 suppresses exchanger activity at high intracellular Na concentrations In cultured rat forebrain neurons it attenuates Ca2 transients induced by glutamate NMDA kainate or KCl with IC50 values ranging from 2 9 to 8 2 M In in vivo studies KB-R7943 reduces endothelin-1 levels and mitigates acute renal dysfunction following ischemic injury This compound is widely utilized in studies investigating Na /Ca2 exchange and related calcium signaling pathways
Apexbio Technology LLC Delavirdine mesylate 147221-93-0 100mg
Delavirdine mesylate (CAS 147221-93-0) is a small-molecule inhibitor targeting HIV-1 reverse transcriptase It is designed to selectively inhibit the enzymatic activity of HIV-1 reverse transcriptase thereby disrupting viral DNA synthesis and impeding HIV replication Delavirdine mesylate exerts its biological activity primarily through direct binding to an allosteric site on HIV-1 reverse transcriptase In biochemical studies delavirdine mesylate demonstrates inhibitory activity against HIV-1 reverse transcriptase with an IC50 value of 0 26 M Based on these pharmacological properties delavirdine mesylate holds research potential in antiviral assays HIV resistance studies and mechanistic investigations into NNRTI-related enzyme inhibition
Apexbio Technology LLC Nafamostat 81525-10-2 10mg
Nafamostat (CAS 81525-10-2) is a small-molecule inhibitor targeting a broad spectrum of serine proteases including thrombin plasmin kallikrein and human trypsin It is designed to block protease-mediated hydrolysis reactions thereby regulating coagulation pathways and inflammation-related protease activity Nafamostat exerts its biological activity primarily through reversible binding to protease active sites inhibiting their enzymatic functions In biochemical assays Nafamostat demonstrates potent inhibitory activity with an IC50 value of approximately 1 10 nM against human trypsin Based on these pharmacological properties Nafamostat holds research potential in coagulation pathway studies inflammation-related protease research pancreatitis modeling and mechanistic investigations of blood coagulation disorders and inflammatory responses
Medchemexpress LLC Gabexate (mesylate) | 56974-61-9 | 98.64% | 100 MG
Gabexate mesylate (FOY) is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. It inhibits human thrombin, urokinase, plasmin, and Factor Xa, and binds to human and bovine tryptase. It is used for pancreatitis and disseminated intravascular coagulation, and decreases proliferation rate in HepG2 cells in vitro.
- Anticoagulant effect by inhibiting the clotting activity of thrombin.
- Anti-inflammatory effect through the inhibition of NF-κB, proinflammatory cytokines, and nitric oxide.
- Therapeutic applications for pancreatitis and disseminated intravascular coagulation.
- Decreases the proliferation rate of HepG2 cells in a dose-dependent manner.
- Attenuates the development of mechanical allodynia induced by spinal nerve ligation (SNL) and inhibits the expression of pro-inflammatory cytokines after SNL in a rat model.
Apexbio Technology LLC Eprosartan Mesylate 144143-96-4 50mg
Eprosartan Mesylate is a small-molecule antagonist targeting the angiotensin II AT1 receptor It is designed to selectively inhibit the AT1 receptor subtype thereby modulating vasoconstriction and aldosterone secretion mechanisms in cardiovascular systems Eprosartan Mesylate exerts its biological activity primarily through competitive binding to AT1 receptors interfering with angiotensin II action In studies using rat and human adrenal cortical membranes Eprosartan Mesylate demonstrates inhibitory activity with IC50 values of approximately 9 2 nM and 3 9 nM respectively Based on these pharmacological properties Eprosartan Mesylate holds research potential in angiotensin II-mediated signal transduction pathways hypertension models and related cardiovascular diseases
Medchemexpress LLC Almitrine mesylate | 29608-49-9 | MFCD01679060 | 99.8% | 669.76 g·mol-1 | C28H37F2N7O6S2 | 100 MG
Almitrine mesylate is a research-grade peripheral chemoreceptor agonist that selectively inhibits Ca2+-dependent K+ channels, used in studies of ventilatory control and pulmonary vascular responses. Supplied as a high-purity salt with solubility and storage guidance for laboratory use.
- High purity (99.8%).
- Molecular weight 669.76 g·mol-1; formula C28H37F2N7O6S2.
- Soluble in DMSO (≈100 mg/mL); in vivo vehicle protocols provided.
- Suitable for in vitro and in vivo pharmacological studies.
- Solid storage at 4°C; in solution store at -80°C up to 6 months.
- Available in small research pack sizes and larger quantities by quote.
Medchemexpress LLC Enasidenib mesylate | 1650550-25-6 | 99.7% | 569.48 | 1 ML
Enasidenib mesylate is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes. It is for research use only.
- Reverses effects of mutant IDH2 on DNA methylation.
- Induces differentiation and impairs self-renewal of IDH2-mutant leukemia cells.
- Improves survival in IDH2-mutant acute myeloid leukemia models.
- Remodels the epigenetic state of IDH2-mutant cells.
- Reduces 2-HG in vivo and restores differentiation.
Medchemexpress LLC AZ7550 mesylate (AZ7550 trimesylate salt) | 2319837-99-3 | 98.7% | 773.90 g·mol⁻¹ | C30H43N7O11S3 | 10 MG
AZ7550 mesylate is the mesylate (trimesylate) salt of AZ7550, an active metabolite of AZD9291 that inhibits IGF1R (IC50 = 1.6 μM). It is provided as an analytical standard for biochemical and cellular research and is offered in small milligram packages and solution formats for assay use.
- Mesylate (trimesylate) salt form for improved handling and solubility.
- Reported IGF1R inhibitory activity with IC50 = 1.6 μM.
- High purity (~98.7%), suitable as an analytical standard.
- Molecular weight 773.90 g·mol⁻¹ and formula C30H43N7O11S3.
- Available in small quantities (5-100 mg) and as DMSO solutions for assay readiness.
Medchemexpress LLC Nafamostat mesylate (FUT-175) | 82956-11-4 | 99.9% | 100 MG
Nafamostat mesylate (FUT-175) is an anticoagulant and a synthetic serine protease inhibitor with demonstrated anticancer and antiviral effects. It induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1) and is used in the development of treatments for pathological thickening of the arterial wall. This compound is intended for research use only.
- Anticoagulant and synthetic serine protease inhibitor
- Exhibits anticancer and antiviral effects
- Induces apoptosis by up-regulating TNFR1 expression
- Inhibits NF-κB activity
- Suppresses invasiveness in Panc-1 cells
- Demonstrates antiviral effects against Zika virus
- Inhibits neointimal formation after balloon injury
Medchemexpress LLC Gabexate mesylate (FOY) | 56974-61-9 | 98.6% | 50 MG
Gabexate mesylate (FOY) is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. It exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effects. It is used for pancreatitis and disseminated intravascular coagulation.
- Inhibits human thrombin, urokinase, plasmin, and Factor Xa
- Binds to human and bovine tryptase
- Attenuates mechanical allodynia in rats
- Decreases HepG2 cell proliferation rate
Medchemexpress LLC Cyclophilin A Mouse 10ug
Cyclophilin A (PPIA) protein with integrin binding and peptidyl-prolyl cis-trans isomerase activity influences platelet aggregation and neuron differentiation It is found in the extracellular space and myelin sheath showing ubiquitous expression in various tissues including the liver and central nervous system PPIA is associated with cholangiocarcinoma and HIV disease suggesting its role in fundamental cellular processes Cyclophilin A Protein Mouse (His) is the recombinant mouse-derived Cyclophilin A protein expressed by E coli with C-His labeled tag
Chemscene trans-Hex-2-enoic acid | 100g | CS-W011247 | 98% | 13419-69-7 | MFCD00002705 | 114 14 | C6H10O2
Chemscene | trans-Hex-2-enoic acid | 100g | CS-W011247 | 98% | 13419-69-7 | MFCD00002705 | 114 14 | C6H10O2